Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy.

ABSTRACT: Whole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. We combined sodium MRI (²³ Na MRI) and ¹ H-MR Spectroscopic Imaging (¹ H-MRSI), assessing changes within epileptogenic networks in comparison with electrophysiologically normal networks as defined by stereotactic EEG (SEEG) recordings analysis. We applied a multi-echo density adapted 3D projection reconstruction pulse sequence at 7 T (²³ Na-MRI) and a 3D echo-planar spectroscopic imaging sequence at 3 T (¹ H-MRSI) in 19 patients suffering from drug-resistant focal epilepsy who underwent presurgical SEEG. We investigated ²³ Na MRI parameters including total sodium concentration (TSC) and the sodium signal fract

SUBMITTER: Azilinon M 

PROVIDER: S-EPMC9842896 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature