Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer.

ABSTRACT:

Background

Basal cell adhesion molecule (BCAM) is a laminin α5 (LAMA5) binding membrane-bound protein with a putative role in cancer. Besides full-length BCAM1, an isoform lacking most of the cytoplasmic domain (BCAM2), and a soluble form (sBCAM) of unknown function are known. In ovarian carcinoma (OC), all BCAM forms are abundant and associated with poor survival, yet BCAM's contribution to peritoneal metastatic spread remains enigmatic.

Methods

Biochemical, omics-based and real-time cell assays were employed to identify the source of sBCAM and metastasis-related functions of different BCAM forms. OC cells, explanted omentum and a mouse model of peritoneal colonisation were used in loss- and gain-of-function experiments.

Results

We identified ADAM10 as a major BCAM s

SUBMITTER: Sivakumar S 

PROVIDER: S-EPMC9842900 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature