Highly connected and highly variable: A Core brain network during resting state supports Propofol-induced unconsciousness.

ABSTRACT: Despite that leading theories of consciousness make diverging predictions for where and how neural activity gives rise to subjective experience, they all seem to partially agree that the neural correlates of consciousness (NCC) require globally integrated brain activity across a network of functionally specialized modules. However, it is not clear yet whether such functional configurations would be able to identify the NCC. We scanned resting-state fMRI data from 21 subjects during wakefulness, propofol-induced sedation, and anesthesia. Graph-theoretical analyses were conducted on awake fMRI data to search for the NCC candidates as brain regions that exhibit both high rich-clubness and high modular variability, which were found to locate in prefrontal and temporoparietal cortices. Another

SUBMITTER: Li S 

PROVIDER: S-EPMC9842907 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature