White matter microstructure shows sex differences in late childhood: Evidence from 6797 children.

ABSTRACT: Sex differences in white matter microstructure have been robustly demonstrated in the adult brain using both conventional and advanced diffusion-weighted magnetic resonance imaging approaches. However, sex differences in white matter microstructure prior to adulthood remain poorly understood; previous developmental work focused on conventional microstructure metrics and yielded mixed results. Here, we rigorously characterized sex differences in white matter microstructure among over 6000 children from the Adolescent Brain Cognitive Development study who were between 9 and 10 years old. Microstructure was quantified using both the conventional model-diffusion tensor imaging (DTI)-and an advanced model, restriction spectrum imaging (RSI). DTI metrics included fractional anisotropy (FA) and m

SUBMITTER: Lawrence KE 

PROVIDER: S-EPMC9842921 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature