Segregation, integration and balance in resting-state brain functional networks associated with bipolar disorder symptoms.

ABSTRACT: Bipolar disorder (BD) is a serious mental disorder involving widespread abnormal interactions between brain regions, and it is believed to be associated with imbalanced functions in the brain. However, how this brain imbalance underlies distinct BD symptoms remains poorly understood. Here, we used a nested-spectral partition (NSP) method to study the segregation, integration, and balance in resting-state brain functional networks in BD patients and healthy controls (HCs). We first confirmed that there was a high deviation in the brain functional network toward more segregation in BD patients than in HCs and that the limbic system had the largest alteration. Second, we demonstrated a network balance of segregation and integration that corresponded to lower anxiety in BD patients but was not

SUBMITTER: Chang Z 

PROVIDER: S-EPMC9842930 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature