Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults.

ABSTRACT:

Background

Immune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frailty is associated with impaired antibody and cellular mRNA vaccine responses.

Methods

We followed older adults in a retirement facility with longitudinal clinical and serological samples from the first Moderna mRNA-1273 vaccine dose starting in February 2021 through their 3rd (booster) vaccine dose. Outcomes were antibody titers, antibody avidity, and AIM+ T cell function and phenotype. Statistical analysis used linear regression with clustered error for antibody titers over multiple timepoints with clinical predictors including, age, sex, prior infection status, and clinical frailty scale (CFS) score. T cell function analysis used linear regre

SUBMITTER: Semelka CT 

PROVIDER: S-EPMC9843107 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature