Improving the accuracy of ³¹P NMR chemical shift calculations by use of scaling methods.

ABSTRACT: Calculation of ³¹P NMR chemical shifts for a series of tri- and tetracoordinate phosphorus compounds using several basis sets and density functional theory (DFT) functionals gave a modest fit to experimental chemical shifts, but an excellent linear fit when plotted against the experimental values. The resultant scaling methods were then applied to a variety of "large" compounds previously selected by Latypov et al. and a set of stereoisomeric and unusual compounds selected here. No one method was best for all structural types. For compounds that contain P-P bonds and P-C multiple bonds, the Latypov et al. method using the PBE0 functional was best (mean absolute deviation/root mean square deviation (MAD/RMSD) = 6.9/8.5 ppm and 6.6/8.2 ppm, respectively), but for the full set of c

SUBMITTER: Hersh WH 

PROVIDER: S-EPMC9843238 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature