Sex differences in the oral microbiome, host traits, and their causal relationships.

ABSTRACT: The oral microbiome has been implicated in a growing number of diseases; however, determinants of the oral microbiome and their roles remain elusive. Here, we investigated the oral (saliva and tongue dorsum) metagenome, the whole genome, and other omics data in a total of 4,478 individuals and demonstrated that the oral microbiome composition and its major contributing host factors significantly differed between sexes. We thus conducted a sex-stratified metagenome-genome-wide-association study (M-GWAS) and identified 11 differential genetic associations with the oral microbiome (p _{sex-difference}  < 5 × 10^-8). Furthermore, we performed sex-stratified Mendelian randomization (MR) analyses and identified abundant causalities between the oral microbiome and

SUBMITTER: Liu X 

PROVIDER: S-EPMC9843272 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature