Right vagus nerve stimulation improves motor behavior by exerting neuroprotective effects in Parkinson's disease rats.

ABSTRACT:

Background

Parkinson's disease (PD) is a common movement disorder disease. Left vagus nerve stimulation (LVNS) is a potential treatment option for PD. Compared with the left vagus nerve, the right vagus nerve is more closely connected with the midbrain dopaminergic neurons, which are the lesion locations of PD. However, whether right vagus nerve stimulation (RVNS) has a therapeutic effect on PD has not yet been studied. Therefore, in this study, we studied the therapeutic effect and underlying mechanism of RVNS using a PD rat model.

Methods

To establish the PD rat model, 8-week-old male Sprague-Dawley rats were intraperitoneally injected with rotenone for 21 days. The cuff electrodes were implanted into the right cervical vagal carotid sheaths of the rats. The right vagus ne

SUBMITTER: Wang C 

PROVIDER: S-EPMC9843310 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature