Metabolomic characterization of congenital microtia: a possible analysis for early diagnosis.

ABSTRACT:

Background

Although metabolic abnormalities have been deemed one of the essential risk factors for growth and development, the relationship between metabolic abnormalities and microtia is still unclear. In this study, we aimed to establish a cell model of microtia and the changes of serum metabolites in patients with microtia.

Methods

After constructing a cell model of microtia with low expression of BMP5, we performed integrative metabolomics analysis. For the altered metabolites, the content of glycerophosphocholine (PC), triacylglycerol (TG), and choline in the serum of 28 patients (15 patients with microtia and 13 controls) with microtia was verified by enzyme-linked immunosorbent assay (ELISA).

Results

Detailed metabolomic evaluation showed distinct clusters of m

SUBMITTER: Chen SJ 

PROVIDER: S-EPMC9843322 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature