Angiotensin-(1-7) alleviates acute lung injury by activating the Mas receptor in neutrophil.

ABSTRACT:

Background

Acute lung injury (ALI) is a major cause of mortality and morbidity in the clinic. None of the current pharmacological interventions has achieved a detectable benefit. The renin-angiotensin system (RAS) is a complex humoral system essentially involved in the regulation of ALI. In the RAS family, angiotensin (Ang)-(1-7) was found to provide protection by counteracting the effects of Ang II in various cardiopulmonary disease models. The downstream receptor of Ang-(1-7) is the G protein-coupled receptor (GPCR) Mas. We hypothesize that the Ang-(1-7)-Mas pathway would protect patients from ALI.

Methods

To establish a 2-hit ALI model, the mice underwent intratracheal instillation of hydrochloric acid followed by ventilator-induced lung injury (VILI). ALI was evaluated b

SUBMITTER: Wang L 

PROVIDER: S-EPMC9843327 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature