Pan-cancer analysis of DEPDC1 as a candidate prognostic biomarker and associated with immune infiltration.

ABSTRACT:

Background

DEP domain containing 1 (DEPDC1) gene is upregulated in several malignancies and contributes to tumorigenesis. Although the role of DEPDC1 in tumor is becoming increasingly popular, the function of DEPDC1 in pan-cancer still needs to be systematically elucidated.

Methods

Data were downloaded from Genotype-Tissue Expression Data (GTEx), The Cancer Genome Atlas (TCGA) TIMER2.0, TISIDB, STRING, and CancerSEA databases and analyzed to determine the functionality of the DEPDC1. The results were visualized using tools provided by the databases and the R language.

Results

The results showed that DEPDC1 was significantly upregulated in 29 of the 33 human cancers analyzed. In addition, there were significant differences in DEPDC1 expression amon

SUBMITTER: Jia B 

PROVIDER: S-EPMC9843344 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature