HPV and radiosensitivity of cervical cancer: a narrative review.

ABSTRACT:

Background and objective

Cervical cancer (CC), the most common gynecological malignancy, is divided into two categories: human papillomavirus-related [HPV positive (HPV+)] and non-HPV-related [HPV negative (HPV-)]. Compared with HPV- CC, HPV+ CC has better radiosensitivity and prognosis. We conducted a literature search and summarized relevant studies to explore the detailed mechanisms by which HPV+ improves the prognosis of CC compared to HPV-.

Methods

PubMed was used to search the literature on human papillomavirus, cervical cancer, and radiotherapy up to June 2022.

Key content and findings

Compared with HPV- CC, HPV+ CC has better radiotherapy outcomes and better prognosis. HPV improves the radiotherapy sensitivity of CC by inhibiting damaged DNA repair, increasing

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9843372 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature