Analysis of gut microbiota in patients with acute myocardial infarction by 16S rRNA sequencing.

ABSTRACT:

Background

An increasing number of studies have shown that gut microbiota are associated with human cardiovascular disease, but the characteristics of intestinal flora in patients with acute myocardial infarction (AMI) are still unclear. In this study, we aimed to investigate the difference of intestinal microflora between patients with AMI and healthy people, and to find the effect of percutaneous coronary intervention (PCI) on intestinal microflora.

Methods

A total of 60 stool samples and 60 peripheral blood samples were collected from 20 previously diagnosed AMI patients and 20 healthy people serving as controls. Gut microbiota communities were analyzed via 16 ribosomal RNA-sequencing (16S rRNA). Gut microbiota-derived metabolites, trimethylamine N-oxide (TMAO) and short-

SUBMITTER: Qian X 

PROVIDER: S-EPMC9843380 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature