Screening key genes related to neuropathic pain-induced depression through an integrative bioinformatics analysis.

ABSTRACT:

Background

Neuropathic pain (NP) is often accompanied by sleep disorders, anxiety, depression and other complications, and the pathogenesis is still unclear. Some drugs can relieve patients' pain, but the overall effect is not good. We screened for the key genes related to NP-induced depression based on bioinformatics.

Methods

The dataset of GSE92718 was obtained from the Gene Expression Omnibus database, data mining was conducted based on R language, the genes modules were screened by weighted correlation network analysis, Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed, a protein-protein interaction (PPI) network was constructed in the STRING database, and hub genes were screened according to degr

SUBMITTER: Li L 

PROVIDER: S-EPMC9843390 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature