Prognostic analysis of RAS-related lncRNAs in liver hepatocellular carcinoma.

ABSTRACT:

Background

Liver hepatocellular carcinoma (LIHC), whose incidence is increasing globally, is one of the most prevalent malignant cancers. RAS-related pathways are involved in the cell proliferation, migration, apoptosis, and metabolism in LIHC. Long noncoding RNAs (lncRNAs) also play important roles in the progression and prognosis of LIHC. However, the clinical role, prognostic significance, and immune regulation of RAS-related lncRNAs in LIHC remains unclear. Our study aims to construct and validate a RAS-related lncRNA prognostic risk signature that can estimate the prognosis and response to immunotherapy in LIHC.

Methods

The clinical information and corresponding messenger RNA (mRNA)/lncRNA expression profiles were obtained from The Cancer Genome Atl

SUBMITTER: Li D 

PROVIDER: S-EPMC9843414 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature