Assessing the generalisability of radiomics features previously identified as predictive of radiation-induced sticky saliva and xerostomia.

ABSTRACT:

Background and purpose

While core to the scientific approach, reproducibility of experimental results is challenging in radiomics studies. A recent publication identified radiomics features that are predictive of late irradiation-induced toxicity in head and neck cancer (HNC) patients. In this study, we assessed the generalisability of these findings.

Materials and methods

The procedure described in the publication in question was applied to a cohort of 109 HNC patients treated with 50-70 Gy in 20-35 fractions using helical radiotherapy although there were inherent differences between the two patient populations and methodologies. On each slice of the planning CT with delineated parotid and submandibular glands, the imaging features that were previously identified as predict

SUBMITTER: Berger T 

PROVIDER: S-EPMC9843480 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature