Aberrant DNA methylation and expression of EYA4 in gastric cardia intestinal metaplasia.

ABSTRACT:

Background

Intestinal metaplasia (IM) of the gastric cardia is an important premalignant lesion. However, there is limited information concerning its epidemiological and molecular features. Herein, we aimed to provide an overview of the epidemiological data for gastric cardiac IM and evaluate the role of EYA transcriptional coactivator and phosphatase 4 (EYA4) as an epigenetic biomarker for gastric cardiac IM.

Methods

The study was conducted in the context of the gastric cardiac precancerous lesion program in southern China, which included 718 non-cancer participants, who undertook endoscopic biopsy and pathological examination in three endoscopy centers, between November 2018 and November 2021. Pyrosequencing and immunohistochemistry were performed to examine the DNA methyl

SUBMITTER: Li C 

PROVIDER: S-EPMC9843510 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature