An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study.

ABSTRACT:

Background

Fibronectin type III domain containing protein 5 (FNDC5) gene encodes irisin that regulates adipose tissue metabolism. Peroxide-proliferator-activated receptor γ coactivator 1α (PGC-1α) is a powerful promoter of mitochondrial biosynthesis and oxidative metabolism, which plays an important role in inducing heat production and energy consumption of brown fat. PGC1-α expression stimulated an increase in expression of FNDC5.

Purpose

The aims of this study were to analyze the association between FNDC5, PGC-1α genetic variants and overweight or obesity in Chinese children and adolescents.

Methods

A total of 198 children and adolescents with overweight or obesity and 198 children and adolescents with normal weight were screened a

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9843619 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature