Chromosome Translocation t(10;19)(q26;q13) in a CIC-sarcoma.

ABSTRACT:

Background/aim

CIC-sarcomas are characterized by rearrangements of the capicua transcriptional repressor (CIC) gene on chromosome subband 19q13.2, generating chimeras in which CIC is the 5'-end partner. Most reported CIC-sarcomas have been detected using PCR amplifications together with Sanger sequencing, high throughput sequencing, and fluorescence in situ hybridization (FISH). Only a few CIC-rearranged tumors have been characterized cytogenetically. Here, we describe the cytogenetic and molecular genetic features of a CIC-sarcoma carrying a t(10;19)(q26;q13), a chromosomal rearrangement not previously detected in such neoplasms.

Materials and methods

A round cell sarcoma removed from the right thigh of a 57-year-old man was investigated by G-banding cytogenetics, FISH, PCR

SUBMITTER: Panagopoulos I 

PROVIDER: S-EPMC9843759 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature