Age-related Differences in Immune Reactions to SARS-CoV-2 Spike and Nucleocapsid Antigens.

ABSTRACT:

Background/aim

The manifestation and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections show a clear correlation to the age of a patient. The younger a person, the less likely the infection results in significant illness. To explore the immunological characteristics behind this phenomenon, we studied the course of SARS-CoV-2 infections in 11 households, including 8 children and 6 infants/neonates of women who got infected with SARS-CoV-2 during pregnancy.

Materials and methods

We investigated the immune responses of peripheral blood mononuclear cells (PBMCs), umbilical cord blood mononuclear cells (UCBCs), and T cells against spike and nucleocapsid antigens of SARS-COV-2 by flow cytometry and cytokine secretion assays.

Results

Upon pep

SUBMITTER: Morhart P 

PROVIDER: S-EPMC9843773 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature