Dynamics of Viral and Host 3D Genome Structure upon Infection.

ABSTRACT: Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated in response to environmental stimuli. This genomic organization is arranged in a hierarchical fashion to support various cellular functions, including transcriptional regulation of gene expression. Like other host cellular mechanisms, viral pathogens utilize and modulate host chromatin architecture and its regulatory machinery to control features of their life cycle, such as lytic versus latent status. Combined with previous research focusing on individual loci, recent global genomic studies employing conformational assays coupled with high-throughput sequencing technology have informed models for host and, in some cases, viral 3D chromosomal structure re-organization during infection and the contrib

SUBMITTER: Friedman MJ 

PROVIDER: S-EPMC9843816 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature