Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil.

ABSTRACT:

Purpose

Regulations have broadened to allow moderate sedation administration for gastrointestinal endoscopy by non-anesthesia personnel. The line between moderate and deep sedation is ambiguous. Deep sedation offers patient comfort as well as greater safety concerns. Unintended deep sedation can occur if drug interactions are overlooked. We present a pharmacodynamic model for moderate sedation using midazolam, alfentanil and propofol. The model is suitable for training and devising rationales for appropriate dosing.

Methods

The study consists of two parts: modeling and validation. In modeling, patients scheduled for esophagogastroduodenoscopy (EGD) or colonoscopy sedation are enrolled. The modified observer's assessment of alertness/sedation (MOAA/S) score < 4 is defined as

SUBMITTER: Liou JY 

PROVIDER: S-EPMC9843845 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature