Genomic and immunogenomic analysis of three prognostic signature genes in LUAD.

ABSTRACT:

Background

Searching for immunotherapy-related markers is an important research content to screen for target populations suitable for immunotherapy. Prognosis-related genes in early stage lung cancer may also affect the tumor immune microenvironment, which in turn affects immunotherapy.

Results

We analyzed the differential genes affecting lung cancer patients receiving immunotherapy through the Cancer Treatment Response gene signature DataBase (CTR-DB), and set a threshold to obtain a total of 176 differential genes between response and non-response to immunotherapy. Functional enrichment analysis found that these differential genes were mainly involved in immune regulation-related pathways. The early-stage lung adenocarcinoma (LUAD) prognostic model was constructed through

SUBMITTER: Feng HM 

PROVIDER: S-EPMC9843910 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature