Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD).

ABSTRACT: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impairs normal brain development and socio-cognitive abilities. The pathogenesis of this condition points out the involvement of genetic and environmental factors during in-utero life. Placenta, as an interface tissue between mother and fetus, provides developing fetus requirements and exposes it to maternal environment as well. Therefore, the alteration of DNA methylation as epigenetic consequence of gene-environmental interaction in the placenta could shed light on ASD pathogenesis. In this study, we reviewed the current findings on placental methylation status and its association with ASD. Differentially methylated regions (DMRs) in ASD-developing placenta were found to be mainly enriched in ASD gene loci affecting syn

SUBMITTER: Ravaei A 

PROVIDER: S-EPMC9843962 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature