Long-term variability in physiological measures in relation to mortality and epigenetic aging: prospective studies in the USA and China.

ABSTRACT:

Background

Visit-to-visit body weight variability (BWV), pulse rate variability (PRV), and blood pressure variability (BPV) have been respectively linked to multiple health outcomes. The associations of the combination of long-term variability in physiological measures with mortality and epigenetic age acceleration (EAA) remain largely unknown.

Methods

We constructed a composite score of physiological variability (0-3) of large variability in BWV, PRV, and BPV (the top tertiles) in 2006/2008-2014/2016 in the Health and Retirement Study (HRS) and 2011-2015 in the China Health and Retirement Longitudinal Study (CHARLS). All-cause mortality was documented through 2018. EAA was calculated using thirteen DNA methylation-based epigenetic clocks among 1047 participants in a substud

SUBMITTER: Chen H 

PROVIDER: S-EPMC9843964 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature