Multiple Sclerosis Is Associated with Immunoglobulin Germline Gene Variation of Transitional B Cells.

ABSTRACT: The regulatory functions of the B-cell compartment play an important role in the development and suppression of the immune response. Disruption of their anti-inflammatory functions may lead to the acceleration of immunopathological processes, and to autoimmune diseases, in particular. Unfortunately, the exact mechanism underlying the functioning and development of regulatory B cells (Breg) has not yet been fully elucidated. Almost nothing is known about their specificity and the structure of their B-cell receptors (BCRs). In this research, we analyzed the BCR repertoire of the transitional Breg (tBreg) subpopulation with the CD19⁺CD24^highCD38^high phenotype in patients with multiple sclerosis (MS), using next-generation sequencing (NGS). We show, for the fir

SUBMITTER: Lomakin YA 

PROVIDER: S-EPMC9844083 | biostudies-literature | 2022 Oct-Dec

REPOSITORIES: biostudies-literature