Image-based cell sorting using focused travelling surface acoustic waves.

ABSTRACT: Sorting cells is an essential primary step in many biological and clinical applications such as high-throughput drug screening, cancer research and cell transplantation. Cell sorting based on their mechanical properties has long been considered as a promising label-free biomarker that could revolutionize the isolation of cells from heterogeneous populations. Recent advances in microfluidic image-based cell analysis combined with subsequent label-free sorting by on-chip actuators demonstrated the possibility of sorting cells based on their physical properties. However, the high purity of sorting is achieved at the expense of a sorting rate that lags behind the analysis throughput. Furthermore, stable and reliable system operation is an important feature in enabling the sorting of small cell

SUBMITTER: Nawaz AA 

PROVIDER: S-EPMC9844123 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature