Antibiotic Safety and Effectiveness in Premature Infants With Complicated Intraabdominal Infections.

ABSTRACT:

Background

In premature infants, complicated intraabdominal infections (cIAIs) are a leading cause of morbidity and mortality. Although universally prescribed, the safety and effectiveness of commonly used antibiotic regimens have not been established in this population.

Methods

Infants ≤33 weeks gestational age and <121 days postnatal age with cIAI were randomized to ≤10 days of ampicillin, gentamicin, and metronidazole (group 1); ampicillin, gentamicin, and clindamycin (group 2); or piperacillin-tazobactam and gentamicin (group 3) at doses stratified by postmenstrual age. Due to slow enrollment, a protocol amendment allowed eligible infants already receiving study regimens to enroll without randomization. The primary outcome was mortality within 30 days of study drug compl

SUBMITTER: Smith MJ 

PROVIDER: S-EPMC9844130 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature