Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ.

ABSTRACT:

Background

The Ca²⁺/calmodulin-dependent protein kinase kinases (CaMKKs) are serine/threonine-directed protein kinases that are activated following increases in intracellular calcium, playing a critical role in neuronal signaling. Inner-ear-trauma-induced calcium overload in sensory hair cells has been well documented in the pathogenesis of traumatic noise-induced hair cell death and hearing loss, but there are no established pharmaceutical therapies available due to a lack of specific therapeutic targets. In this study, we investigated the activation of CaMKKβ in the inner ear after traumatic noise exposure and assessed the prevention of noise-induced hearing loss (NIHL) with RNA silencing.

Results

Treatment with short hairpin RNA of CaMKKβ (shCaMKKβ) via adeno-a

SUBMITTER: Wu F 

PROVIDER: S-EPMC9844253 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature