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New Insights into Risk Genes and Their Candidates in Multiple Sclerosis.

ABSTRACT: Oligodendrocytes are central nervous system glial cells that wrap neuronal axons with their differentiated myelin membranes as biological insulators. There has recently been an emerging concept that multiple sclerosis could be triggered and promoted by various risk genes that appear likely to contribute to the degeneration of oligodendrocytes. Despite the known involvement of vitamin D, immunity, and inflammatory cytokines in disease progression, the common causes and key genetic mechanisms remain unknown. Herein, we focus on recently identified risk factors and risk genes in the background of multiple sclerosis and discuss their relationships.

SUBMITTER: Shirai R

PROVIDER: S-EPMC9844300 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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New Insights into Risk Genes and Their Candidates in Multiple Sclerosis.

Shirai Remina R Yamauchi Junji J

Neurology international 20221229 1

Oligodendrocytes are central nervous system glial cells that wrap neuronal axons with their differentiated myelin membranes as biological insulators. There has recently been an emerging concept that multiple sclerosis could be triggered and promoted by various risk genes that appear likely to contribute to the degeneration of oligodendrocytes. Despite the known involvement of vitamin D, immunity, and inflammatory cytokines in disease progression, the common causes and key genetic mechanisms rema ...[more]

PMID: 36648967

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