Self-Assembly, Self-Folding, and Origami: Comparative Design Principles.

ABSTRACT: Self-assembly is usually considered a parallel process while self-folding and origami are usually considered to be serial processes. We believe that these distinctions do not hold in actual experiments. Based upon our experience with 4D printing, we have developed three additional hybrid classes: (1) templated-assisted (tethered) self-assembly: e.g., when RNA is bound to viral capsomeres, the subunits are constricted in their interactions to have aspects of self-folding as well; (2) self-folding can depend upon interactions with the environment; for example, a protein synthesized on a ribosome will fold as soon as peptides enter the intracellular environment in a serial process whereas if denatured complete proteins are put into solution, parallel folding can occur simultaneously; and, (3)

SUBMITTER: Jungck JR 

PROVIDER: S-EPMC9844370 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature