Roles for the RNA-Binding Protein Caper in Reproductive Output in Drosophila melanogaster.

ABSTRACT: RNA binding proteins (RBPs) play a fundamental role in the post-transcriptional regulation of gene expression within the germline and nervous system. This is underscored by the prevalence of mutations within RBP-encoding genes being implicated in infertility and neurological disease. We previously described roles for the highly conserved RBP Caper in neurite morphogenesis in the Drosophila larval peripheral system and in locomotor behavior. However, caper function has not been investigated outside the nervous system, although it is widely expressed in many different tissue types during embryogenesis. Here, we describe novel roles for Caper in fertility and mating behavior. We find that Caper is expressed in ovarian follicles throughout oogenesis but is dispensable for proper

SUBMITTER: Tixtha EJ 

PROVIDER: S-EPMC9844462 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature