Racial Differences in Val122Ile-Associated Transthyretin Cardiac Amyloidosis.

ABSTRACT:

Background

The valine-to-isoleucine substitution (Val122Ile) is the most common variant of transthyretin (TTR) amyloidosis in the United States, affecting primarily individuals of African descent. This variant has been identified recently in a cluster of white individuals in Italy.

Methods and results

Clinical phenotype and chamber performance of Black and white individuals with Val122Ile TTR cardiac amyloidosis (ATTR-CA) were compared. Compared to white patients (n = 17), Black individuals (n = 53) had lower systolic blood pressures (110 vs 131 mmHg, <0.001), reduced pulse pressures (41 vs 58 mmHg; P < 0.001), and impaired renal function (eGFR 46 vs 67 mL/min/1.73m²; P < 0.001) at presentation. Systolic properties and arterial elastance were similar. Black patien

SUBMITTER: Batra J 

PROVIDER: S-EPMC9844506 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature