Adenoviral-based vaccine promotes neoantigen-specific CD8⁺ T cell stemness and tumor rejection.

ABSTRACT: Upon chronic antigen exposure, CD8⁺ T cells become exhausted, acquiring a dysfunctional state correlated with the inability to control infection or tumor progression. In contrast, stem-like CD8⁺ T progenitors maintain the ability to promote and sustain effective immunity. Adenovirus (Ad)-vectored vaccines encoding tumor neoantigens have been shown to eradicate large tumors when combined with anti-programmed cell death protein 1 (αPD-1) in murine models; however, the mechanisms and translational potential have not yet been elucidated. Here, we show that gorilla Ad vaccine targeting tumor neoepitopes enhances responses to αPD-1 therapy by improving immunogenicity and antitumor efficacy. Single-cell RNA sequencing demonstrated that the combination of Ad vaccine and αPD-1

SUBMITTER: D'Alise AM 

PROVIDER: S-EPMC9844517 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature