Characterization of RNA modifications in gastric cancer to identify prognosis-relevant gene signatures.

ABSTRACT:

Background

Most human genes have diverse transcript isoforms, which mainly arise from alternative cleavage and polyadenylation (APA) at 3' ends. N7-methylguanosine (m⁷ G) is also an essential epigenetic modification at the 5' end. However, the contribution of these two RNA modifications to the development, prognosis, regulation mechanisms, and drug sensitivity of gastric cancer (GC) is unclear.

Methods

The expression data of 2412 patients were extracted from 12 cohorts and the RNA modification patterns of 20 marker genes were systematically identified into phenotypic clusters using the unsupervised clustering approach. Following that, we developed an RNA modification model (RMscore) to quantify each GC patient's RNA modification index. Finally, we examined the cor

SUBMITTER: Chen Q 

PROVIDER: S-EPMC9844604 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature