DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.

ABSTRACT:

Background

Drug resistance is an important factor affecting the efficacy of chemotherapy in patients with colon cancer. However, clinical markers for diagnosing drug resistance of tumor cells are not only a few in number, but also low in specificity, and the mechanism of action of tumor cell drug resistance remains unclear.

Methods

Dipeptidase 1 (DPEP1) expression was analyzed using the cancer genome atlas (TCGA) and genotype-Tissue Expression pan-cancer data. Survival analysis was performed using the survival package in R software to assess the prognostic value of DPEP1 expression in colon cancer. Correlation and Venn analyses were adopted to identify key genes. Immunohistochemistry, western blot, qRT-PCR, Co-immunoprecipitation, and dual-luciferase reporter experiments wer

SUBMITTER: Zeng C 

PROVIDER: S-EPMC9844606 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature