Impact of concomitant fibrates on immunotherapy outcomes for advanced non-small cell lung cancer.

ABSTRACT:

Background

Peroxisome proliferator-activated receptor agonists such as fibrates restore oxidative metabolism in cytotoxic T-lymphocytes, thereby enhancing response to immune checkpoint inhibitors (ICI) in preclinical models. However, there is no evidence in humans on the clinical impact of fibrates as an adjunct to ICI.

Methods

In this cohort study of Veterans with non-small cell lung cancer (NSCLC) receiving ICI, fibrate exposure was defined as a prescription filled within 90 days of an ICI infusion. Overall survival (OS), measured from the start of ICI, was compared between exposed and unexposed Veterans. Cox multivariable analysis (MVA) was used to identify factors associated with OS. A sensitivity analysis of Veterans with stage IV NSCLC who received docetaxel without IC

SUBMITTER: Stokes WA 

PROVIDER: S-EPMC9844615 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature