Comprehensive analysis of metabolic pathway activity subtypes derived prognostic signature in hepatocellular carcinoma.

ABSTRACT:

Objective

Metabolic reprogramming is one of the hallmarks of cancer, but metabolic pathway activity-related subtypes of hepatocellular carcinoma (HCC) have not been identified.

Methods

Based on the quantification results of 41 metabolic pathway activities by gene set variation analysis, the training cohort (n = 609, merged by TCGA and GSE14520) was clustered into three subtypes (C1, C2, and C3) with the nonnegative matrix factorization method. Totally 1371 differentially expressed genes among C1, C2, and C3 were identified, and an 8-gene risk score was established by univariable Cox regression analysis, least absolute shrinkage and selection operator method, and multivariable Cox regression analysis.

Results

C1 had the strongest metabolic activity, good prognosis, the

SUBMITTER: Huo J 

PROVIDER: S-EPMC9844627 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature