Derivation and validation of a risk classification tree for patients with synovial sarcoma.

ABSTRACT:

Background

Synovial sarcoma (SS) accounts for 8%-10% of all soft-tissue sarcomas. Clinical presentation and outcomes vary, yet discrete risk groups based on validated prognostic indices are not defined for the full spectrum of patients with SS.

Methods

We performed a retrospective cohort study using data from the SEER (surveillance, epidemiology, and end results program) database of SS patients who were <70 years of age at diagnosis. We constructed a recursive partitioning model of overall survival using a training cohort of 1063 patients with variables: Age at diagnosis, sex, race, ethnicity, primary site, tumor size, tumor grade, and stage. Based on this model, we grouped patients into three risk groups and estimated 5-year overall survival for each group. We then applied

SUBMITTER: Neel DV 

PROVIDER: S-EPMC9844650 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature