Statins associate with lower risk of biliary tract cancers: A systematic review and meta-analysis.

ABSTRACT:

Background

Biliary tract cancers (BTCs), encompassing cholangiocarcinoma (CCA), gallbladder (GBC), and ampulla of Vater cancers (AVC), are common hepatobiliary cancer after hepatocellular carcinoma with a high mortality rate. As there is no effective chemopreventive agent to prevent BTCs, this study aimed to explore the role of statins on the risk of BTCs.

Methods

PubMed, Embase, and Cochrane Library from inception until 24 April 2020 were searched according to the Meta-Analyses of Observational Studies in Epidemiology (MOOSE) guidelines. The adjusted risk ratios (aRRs) of BTCs and individual cancer were pooled using a random-effects model.

Results

Eight observational studies (3 cohort and 5 case-control studies) were included with 10,485,231 patients. The median age

SUBMITTER: Cheung KS 

PROVIDER: S-EPMC9844660 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature