Characteristics of salivary telomere length shortening in preterm infants.

ABSTRACT:

Objective

To examine the association between gestational age, telomere length (TL) and rate of shortening in newborns.

Study design

Genomic DNA was isolated from buccal samples of 39 term infants at birth and one year and 32 preterm infants at birth, term-adjusted age (40 weeks post-conception) and age one-year corrected for gestational duration. Telomere length was measured by quantitative real-time PCR. Demographic and clinical data were collected during clinic or research visits and from hospital records. Socioeconomic status was estimated using the deprivation category (DEPCAT) scores derived from the Carstairs score of the subject's postal code.

Results

At birth, preterm infants had longer telomeres than infants born at term. However, there was no difference in t

SUBMITTER: Schneper LM 

PROVIDER: S-EPMC9844854 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature