HIV and SARS-CoV-2 infection in postpartum Kenyan women and their infants.

ABSTRACT:

Background

HIV may increase SARS-CoV-2 infection risk and COVID-19 severity generally, but data are limited about its impact on postpartum women and their infants. As such, we characterized SARS-CoV-2 infection among mother-infant pairs in Nairobi, Kenya.

Methods

We conducted a nested study of 62 HIV-uninfected and 64 healthy women living with HIV, as well as their HIV-exposed uninfected (N = 61) and HIV-unexposed (N = 64) infants, participating in a prospective cohort. SARS-CoV-2 serology was performed on plasma collected between May 1, 2020-February 1, 2022 to determine the incidence, risk factors, and symptoms of infection. SARS-CoV-2 RNA PCR and sequencing was also performed on available stool samples from seropositive participants.

Results

SARS-CoV-2 seropositivi

SUBMITTER: Begnel ER 

PROVIDER: S-EPMC9844875 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature