Immune-related pan-cancer gene expression signatures of patient survival revealed by NanoString-based analyses.

ABSTRACT: The immune system plays a central role in the onset and progression of cancer. A better understanding of transcriptional changes in immune cell-related genes associated with cancer progression, and their significance in disease prognosis, is therefore needed. NanoString-based targeted gene expression profiling has advantages for deployment in a clinical setting over RNA-seq technologies. We analysed NanoString PanCancer Immune Profiling panel gene expression data encompassing 770 genes, and overall survival data, from multiple previous studies covering 10 different cancer types, including solid and blood malignancies, across 515 patients. This analysis revealed an immune gene signature comprising 39 genes that were upregulated in those patients with shorter overall survival; of these 39 ge

SUBMITTER: D'Angelo A 

PROVIDER: S-EPMC9844904 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature