Dietary exposure to nitrites and nitrates in association with type 2 diabetes risk: Results from the NutriNet-Sante population-based cohort study.

ABSTRACT:

Background

Nitrites and nitrates occur naturally in water and soil and are commonly ingested from drinking water and dietary sources. They are also used as food additives, mainly in processed meats, to increase shelf life and to avoid bacterial growth. Experimental studies suggested both benefits and harmful effects of nitrites and nitrates exposure on type 2 diabetes (T2D) onset, but epidemiological and clinical data are lacking. We aimed to study these associations in a large population-based prospective cohort study, distinguishing foods and water-originated nitrites/nitrates from those from food additives.

Methods and findings

Overall, 104,168 adults from the French NutriNet-Santé cohort study (2009 to 2021, 79.1% female, mean age [SD] = 42.7 [14.5]) were included. Assoc

SUBMITTER: Srour B 

PROVIDER: S-EPMC9844911 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature