Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring : A Nationwide Cohort Study.

ABSTRACT:

Background

Diabetes reduces semen quality and increasingly occurs during reproductive years. Diabetes medications, such as metformin, have glucose-independent effects on the male reproductive system. Associations with birth defects in offspring are unknown.

Objective

To evaluate whether the risk for birth defects in offspring varies with preconceptional pharmacologic treatment of fathers with diabetes.

Design

Nationwide prospective registry-based cohort study.

Setting

Denmark from 1997 to 2016.

Participants

All liveborn singletons from mothers without histories of diabetes or essential hypertension.

Measurements

Offspring were considered exposed if their father filled 1 or more prescriptions for a diabetes drug during the development of fertilizin

SUBMITTER: Wensink MJ 

PROVIDER: S-EPMC9844982 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature