Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled.

ABSTRACT: Elaborate behaviours are produced by tightly controlled flexor-extensor motor neuron activation patterns. Motor neurons are regulated by a network of interneurons within the spinal cord, but the computational processes involved in motor control are not fully understood. The neuroanatomical arrangement of motor and premotor neurons into topographic patterns related to their controlled muscles is thought to facilitate how information is processed by spinal circuits. Rabies retrograde monosynaptic tracing has been used to label premotor interneurons innervating specific motor neuron pools, with previous studies reporting topographic mediolateral positional biases in flexor and extensor premotor interneurons. To more precisely define how premotor interneurons contacting specific motor pools ar

SUBMITTER: Ronzano R 

PROVIDER: S-EPMC9844990 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature