Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population.

ABSTRACT:

Purpose

The health correlates of polygenic risk (PRS-SCZ) and exposome (ES-SCZ) scores for schizophrenia may vary depending on age and sex. We aimed to examine age- and sex-specific associations of PRS-SCZ and ES-SCZ with self-reported health in the general population.

Methods

Participants were from the population-based Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2). Mental and physical health were measured with the 36-item Short Form Survey 4 times between 2007 and 2018. The PRS-SCZ and ES-SCZ were respectively calculated from common genetic variants and exposures (cannabis use, winter birth, hearing impairment, and five childhood adversity categories). Moderation by age and sex was examined in linear mixed models.

Results

For PRS-SCZ and ES-SCZ a

SUBMITTER: Paquin V 

PROVIDER: S-EPMC9845157 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature