Prognostic implication and immunotherapy response prediction of a ubiquitination-related gene signature in breast cancer.

ABSTRACT: Breast cancer (BC) is one of the most common tumor types and has poor outcomes. In this study, a ubiquitination-related prognostic signature was constructed, and its association with immunotherapy response in BC was explored. A list of ubiquitination-related genes was obtained from the molecular signatures database, and a ubiquitination-related gene signature was obtained by least absolute shrinkage and selection operator Cox regression. The genes, TCN1, DIRAS3, and IZUMO4, had significant influence on BC outcomes. Patients were categorized into two clusters-a high-risk group with poor survival and a low-risk group with greater chances of controlling BC progression. Univariate and multivariate Cox regression analyses revealed that the risk signature was an independent

SUBMITTER: Hong K 

PROVIDER: S-EPMC9845272 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature