Differential DNA methylation associated with multiple sclerosis and disease modifying treatments in an underrepresented minority population.

ABSTRACT: Black and Hispanic American patients frequently develop earlier onset of multiple sclerosis (MS) and a more severe disease course that can be resistant to disease modifying treatments. The objectives were to identify differential methylation of genomic DNA (gDNA) associated with disease susceptibility and treatment responses in a cohort of MS patients from underrepresented minority populations. Patients with MS and controls with non-inflammatory neurologic conditions were consented and enrolled under an IRB-approved protocol. Approximately 64% of donors identified as Black or African American and 30% as White, Hispanic-Latino. Infinium MethylationEPIC bead arrays were utilized to measure epigenome-wide gDNA methylation of whole blood. Data were analyzed in the presence and absence of adjus

SUBMITTER: Bingen JM 

PROVIDER: S-EPMC9845287 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature